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Eukaryotic Gene Regulation and Chromatin Remodeling<\/strong><\/p>\n\n

By<\/strong><\/p>\n\n

Dr.V.Malathi<\/strong><\/p>\n\n

Associate Professor<\/p>\n\n

Department of Biochemistry<\/p>\n\n

Ethiraj College for Women<\/p>\n\n

Chennai-60008<\/p>\n\n

Tamil Nadu<\/p>\n\n

India<\/p>\n\n

<\/p>\n","coverMedium":{"library":"H5P.Image 1.1","metadata":{"contentType":"Image","license":"CC BY","title":"The chromatin signature of pluripotent cells","authors":[{"name":"Sha-Boyer","role":"Author"}],"source":"https:\/\/en.wikipedia.org\/wiki\/File:Sha-Boyer-Fig1-CCBy3.0.jpg","licenseVersion":"3.0"},"params":{"contentName":"Image","decorative":false,"alt":"Lets learn about Gene Regulation in Eukaryotes and Chromatin Remodeling","file":{"path":"images\/image-k95x8tRN.jpg","mime":"image\/jpeg","width":606,"height":537,"originalImage":{"path":"images\/image-URLwGpSc.jpg","mime":"image\/jpeg","height":538,"width":607}}},"subContentId":"b3c1df5b-5d9d-4f8f-8150-64c5bc4b4160"}},"chapters":[{"params":{"content":[{"content":{"params":{"presentation":{"slides":[{"elements":[{"x":3.139717425431711,"y":15.505077913016512,"width":33.15353218210361,"height":62.02031165206605,"action":{"library":"H5P.Image 1.1","params":{"contentName":"Image","file":{"path":"images\/image-B3tfsl96.png","mime":"image\/png","copyright":{"license":"U"},"width":742,"height":559,"originalImage":{"path":"images\/image-Tg082P8m.png","mime":"image\/png","height":1350,"width":1791}},"alt":"DNA-Genes-Chromatin-Chromosomes"},"subContentId":"868ead32-56fb-478f-baf0-3128f387c2c5","metadata":{"contentType":"Image","license":"CC BY-SA","title":"Chromosome-DNA-Gene","authors":[{"name":"Thomas Splettstoesser","role":"Author"}],"licenseVersion":"4.0","yearFrom":2015}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":37.67660910518054,"y":12.40406233041321,"width":61.224489795918366,"height":74.42437398247925,"action":{"library":"H5P.AdvancedText 1.1","params":{"text":"

\n\t
Gene is the basic unit of heredity .<\/span><\/span><\/li>\n\t
It is the sequence of nucleotides in a DNA that encode either for a RNA or a Protein<\/span><\/span><\/li>\n\t
DNA binds with histone proteins, forms Nucleosomes and is condensed in an orderly fashion to Chromatin<\/span><\/span><\/li>\n\t
Chromatin condenses to form the Chromosome.<\/span><\/span><\/li>\n<\/ul>\n\n
<\/p>\n"},"subContentId":"d04ada38-8e34-4a19-b8fc-c32a251c7029","metadata":{"contentType":"Text","license":"CC BY-SA","title":"What are Genes?","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":6.279434850863422,"y":80.62640514768586,"width":31.39717425431711,"height":10.543452980851228,"action":{"library":"H5P.AdvancedText 1.1","params":{"text":"
DNA-Genes-Chromatin-Chromosomes<\/strong><\/p>\n"},"subContentId":"0167f7ec-b37d-452d-b8b8-e2ca1b49c2b5","metadata":{"contentType":"Text","license":"U","title":"Untitled Text"}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""}],"slideBackgroundSelector":{}},{"elements":[{"x":6.279434850863422,"y":15.505077913016512,"width":89.48194662480377,"height":71.32335839987596,"action":{"library":"H5P.DragText 1.10","params":{"taskDescription":"Drag the words into the correct boxes","overallFeedback":[{"from":0,"to":100}],"checkAnswer":"Check","submitAnswer":"Submit","tryAgain":"Retry","showSolution":"Show solution","dropZoneIndex":"Drop Zone @index.","empty":"Drop Zone @index is empty.","contains":"Drop Zone @index contains draggable @draggable.","ariaDraggableIndex":"@index of @count draggables.","tipLabel":"Show tip","correctText":"Correct!","incorrectText":"Incorrect!","resetDropTitle":"Reset drop","resetDropDescription":"Are you sure you want to reset this drop zone?","grabbed":"Draggable is grabbed.","cancelledDragging":"Cancelled dragging.","correctAnswer":"Correct answer:","feedbackHeader":"Feedback","behaviour":{"enableRetry":true,"enableSolutionsButton":true,"enableCheckButton":true,"instantFeedback":false},"scoreBarLabel":"You got :num out of :total points","a11yCheck":"Check the answers. The responses will be marked as correct, incorrect, or unanswered.","a11yShowSolution":"Show the solution. The task will be marked with its correct solution.","a11yRetry":"Retry the task. Reset all responses and start the task over again.","textField":"*Genes* are the fundamental unit of heredity \n*Nucleotide sequence* of DNA that code for RNA or Protein is Gene\nCondensed form of DNA is *Chromatin*\nChromatin upon condensation become * Chromosomes*\n* Histones*are the proteins that bind with DNA to condense it"},"subContentId":"5c9abfd9-7cbc-4912-8ea8-ed22e0dcfd13","metadata":{"contentType":"Drag the Words","license":"CC BY-SA","title":"Test your Understanding","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""}],"slideBackgroundSelector":{}},{"elements":[{"x":6.279434850863423,"y":18.606093495619813,"width":87.91208791208791,"height":71.94356151639661,"action":{"library":"H5P.Dialogcards 1.9","params":{"mode":"normal","description":"
<\/p>\n","dialogs":[{"tips":{},"text":"
The blue print of an organism<\/p>\n","answer":"
DNA<\/p>\n","image":{"path":"images\/image-ONYcyGbd.png","mime":"image\/png","copyright":{"license":"CC BY-SA","author":"Michael Str\u00f6ck","title":"DNA","year":"2006","source":"https:\/\/en.wikipedia.org\/wiki\/File:Diagram_of_DNA_Structure.png#filelinks","version":"3.0"},"width":522,"height":899},"imageAltText":"The blue print of an organism"},{"tips":{},"text":"
\"Bead on String arrangement\"<\/p>\n","answer":"
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Basic Proteins that bind with the DNA<\/p>\n","answer":"
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Formation of Nucleosomes <\/p>\n","
Formatin of 30 nm fibre <\/p>\n","
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Gene expression<\/strong> is the process by which genes in the cell are turned on..<\/span><\/li>\n\t
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Gene Expression<\/strong><\/p>\n"},"subContentId":"b4549e18-77c3-495d-9071-c3d1f8e788ef","metadata":{"contentType":"Text","license":"U","title":"Untitled Text"}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""}],"slideBackgroundSelector":{}},{"elements":[{"x":45.52590266875981,"y":6.202031165206605,"width":51.80533751962323,"height":83.72742073028917,"action":{"library":"H5P.AdvancedText 1.1","params":{"text":"
\n\t
Transcription<\/strong> is the Process by which the information in the DNA is copied or transcribed as an RNA in the Nucleus of the cell.<\/span><\/li>\n\t
Translation<\/strong> is the process by which the codes in the m RNA are read and made in to a protein.<\/span><\/li>\n\t
This process takes place in the cytosol of the cell<\/span><\/li>\n\t
Thus by gene expression the information coded in the DNA in the nucleus is decoded as a protein in the cytosol..<\/span><\/li>\n\t
Humans have nearly 20,000 genes <\/strong>.<\/span><\/li>\n\t
Not all genes are made in to proteins .<\/strong><\/span><\/li>\n\t
Some genes are never translated . Example genes of Ribozymes <\/span><\/li>\n<\/ul>\n\n
<\/p>\n\n
<\/p>\n"},"subContentId":"30c39110-33e5-4049-80e7-641732627cff","metadata":{"contentType":"Text","license":"CC BY-SA","title":"Gene expression regulation","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":1.5698587127158554,"y":12.40406233041321,"width":42.3861852433281,"height":71.32335839987596,"action":{"library":"H5P.Image 1.1","params":{"contentName":"Image","file":{"path":"images\/image-S0FOdvHB.png","mime":"image\/png","copyright":{"license":"U"},"width":870,"height":330},"alt":"Gene Expression"},"subContentId":"61cc5507-c47a-46ec-856a-05d7dac4f21d","metadata":{"contentType":"Image","license":"CC BY-SA","title":"Genetic code","authors":[{"name":"Madprime, CC0, via Wikimedia Commons","role":"Author"}],"licenseVersion":"2.5","yearFrom":2007,"source":"https:\/\/commons.wikimedia.org\/wiki\/File:Genetic_code.svg"}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""}],"slideBackgroundSelector":{}},{"elements":[{"x":3.1397174254317113,"y":18.606093495619813,"width":50.23547880690738,"height":55.81828048685944,"action":{"library":"H5P.Blanks 1.14","params":{"media":{"disableImageZooming":false},"text":"Fill in the missing words","overallFeedback":[{"from":0,"to":100}],"showSolutions":"Show solution","tryAgain":"Retry","checkAnswer":"Check","submitAnswer":"Submit","notFilledOut":"Please fill in all blanks to view solution","answerIsCorrect":"':ans' is correct","answerIsWrong":"':ans' is wrong","answeredCorrectly":"Answered correctly","answeredIncorrectly":"Answered incorrectly","solutionLabel":"Correct answer:","inputLabel":"Blank input @num of @total","inputHasTipLabel":"Tip available","tipLabel":"Tip","behaviour":{"enableRetry":true,"enableSolutionsButton":true,"enableCheckButton":true,"autoCheck":false,"caseSensitive":true,"showSolutionsRequiresInput":true,"separateLines":false,"confirmCheckDialog":false,"confirmRetryDialog":false,"acceptSpellingErrors":false},"scoreBarLabel":"You got :num out of :total points","a11yCheck":"Check the answers. The responses will be marked as correct, incorrect, or unanswered.","a11yShowSolution":"Show the solution. The task will be marked with its correct solution.","a11yRetry":"Retry the task. Reset all responses and start the task over again.","a11yCheckingModeHeader":"Checking mode","confirmCheck":{"header":"Finish ?","body":"Are you sure you wish to finish ?","cancelLabel":"Cancel","confirmLabel":"Finish"},"confirmRetry":{"header":"Retry ?","body":"Are you sure you wish to retry ?","cancelLabel":"Cancel","confirmLabel":"Confirm"},"questions":["
1.The molecular on\/ off switches of genes are controlled by *Gene Expression*<\/p>\n\n
<\/p>\n"]},"subContentId":"6eb56e01-b81a-4161-a931-783b25eaa40d","metadata":{"contentType":"Fill in the Blanks","license":"CC BY-SA","title":"Fill in the Blanks","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":56.514913657770805,"y":12.40406233041321,"width":40,"height":58.919296069462746,"action":{"library":"H5P.MultiChoice 1.16","params":{"media":{"disableImageZooming":false},"answers":[{"correct":false,"tipsAndFeedback":{"tip":"","chosenFeedback":"","notChosenFeedback":""},"text":"
Cytosol<\/div>\n"},{"correct":false,"tipsAndFeedback":{"tip":"","chosenFeedback":"","notChosenFeedback":""},"text":"
Ribosomes<\/div>\n"},{"correct":true,"tipsAndFeedback":{"tip":"","chosenFeedback":"","notChosenFeedback":""},"text":"
Nucleus<\/div>\n"}],"overallFeedback":[{"from":0,"to":100}],"behaviour":{"enableRetry":true,"enableSolutionsButton":true,"enableCheckButton":true,"type":"auto","singlePoint":false,"randomAnswers":true,"showSolutionsRequiresInput":true,"confirmCheckDialog":false,"confirmRetryDialog":false,"autoCheck":false,"passPercentage":100,"showScorePoints":true},"UI":{"checkAnswerButton":"Check","submitAnswerButton":"Submit","showSolutionButton":"Show solution","tryAgainButton":"Retry","tipsLabel":"Show tip","scoreBarLabel":"You got :num out of :total points","tipAvailable":"Tip available","feedbackAvailable":"Feedback available","readFeedback":"Read feedback","wrongAnswer":"Wrong answer","correctAnswer":"Correct answer","shouldCheck":"Should have been checked","shouldNotCheck":"Should not have been checked","noInput":"Please answer before viewing the solution","a11yCheck":"Check the answers. The responses will be marked as correct, incorrect, or unanswered.","a11yShowSolution":"Show the solution. The task will be marked with its correct solution.","a11yRetry":"Retry the task. Reset all responses and start the task over again."},"confirmCheck":{"header":"Finish ?","body":"Are you sure you wish to finish ?","cancelLabel":"Cancel","confirmLabel":"Finish"},"confirmRetry":{"header":"Retry ?","body":"Are you sure you wish to retry ?","cancelLabel":"Cancel","confirmLabel":"Confirm"},"question":"
The process of Transcription takes place in the -----<\/p>\n"},"subContentId":"b205f15d-09cf-4fb6-bf30-c72469a64119","metadata":{"contentType":"Multiple Choice","license":"CC BY-SA","title":"Multiple Choice","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""}],"slideBackgroundSelector":{}},{"elements":[{"x":4.709576138147567,"y":21.707109078223116,"width":94.19152276295134,"height":68.22234281727265,"action":{"library":"H5P.DragText 1.10","params":{"taskDescription":"Drag the words into the correct boxes","overallFeedback":[{"from":0,"to":100}],"checkAnswer":"Check","submitAnswer":"Submit","tryAgain":"Retry","showSolution":"Show solution","dropZoneIndex":"Drop Zone @index.","empty":"Drop Zone @index is empty.","contains":"Drop Zone @index contains draggable @draggable.","ariaDraggableIndex":"@index of @count draggables.","tipLabel":"Show tip","correctText":"Correct!","incorrectText":"Incorrect!","resetDropTitle":"Reset drop","resetDropDescription":"Are you sure you want to reset this drop zone?","grabbed":"Draggable is grabbed.","cancelledDragging":"Cancelled dragging.","correctAnswer":"Correct answer:","feedbackHeader":"Feedback","behaviour":{"enableRetry":true,"enableSolutionsButton":true,"enableCheckButton":true,"instantFeedback":false},"scoreBarLabel":"You got :num out of :total points","a11yCheck":"Check the answers. The responses will be marked as correct, incorrect, or unanswered.","a11yShowSolution":"Show the solution. The task will be marked with its correct solution.","a11yRetry":"Retry the task. Reset all responses and start the task over again.","textField":"*Translation* is the process by which proteins are made \nTranslation takes place in the *Cytosol* of the cell\nTranscription and Translation is * Gene expression*\n*Transcription* is the process of making a RNA\n* RNA polymerases* are the enzymes required for transcription"},"metadata":{"contentType":"Drag the Words","license":"CC BY-SA","title":"Drag the Words","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022},"subContentId":"fc8e9e83-f845-4ec0-a7ce-870d1657910d"},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""}],"slideBackgroundSelector":{}},{"elements":[{"x":7.849293563579278,"y":37.212186991239626,"width":40,"height":40,"action":{"library":"H5P.TrueFalse 1.8","params":{"media":{"disableImageZooming":false},"correct":"false","behaviour":{"enableRetry":true,"enableSolutionsButton":true,"enableCheckButton":true,"confirmCheckDialog":false,"confirmRetryDialog":false,"autoCheck":false},"l10n":{"trueText":"True","falseText":"False","score":"You got @score of @total points","checkAnswer":"Check","submitAnswer":"Submit","showSolutionButton":"Show solution","tryAgain":"Retry","wrongAnswerMessage":"Wrong answer","correctAnswerMessage":"Correct answer","scoreBarLabel":"You got :num out of :total points","a11yCheck":"Check the answers. The responses will be marked as correct, incorrect, or unanswered.","a11yShowSolution":"Show the solution. The task will be marked with its correct solution.","a11yRetry":"Retry the task. Reset all responses and start the task over again."},"confirmCheck":{"header":"Finish ?","body":"Are you sure you wish to finish ?","cancelLabel":"Cancel","confirmLabel":"Finish"},"confirmRetry":{"header":"Retry ?","body":"Are you sure you wish to retry ?","cancelLabel":"Cancel","confirmLabel":"Confirm"},"question":"
All genes are translated to Proteins <\/p>\n"},"subContentId":"d9463192-c826-4394-8b83-9ccc83294ded","metadata":{"contentType":"True\/False Question","license":"CC BY-SA","title":"True\/False Question","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":54.94505494505494,"y":9.303046747809907,"width":43.13971742543171,"height":39.999379796883474,"action":{"library":"H5P.TrueFalse 1.8","params":{"media":{"disableImageZooming":false},"correct":"false","behaviour":{"enableRetry":true,"enableSolutionsButton":true,"enableCheckButton":true,"confirmCheckDialog":false,"confirmRetryDialog":false,"autoCheck":false},"l10n":{"trueText":"True","falseText":"False","score":"You got @score of @total points","checkAnswer":"Check","submitAnswer":"Submit","showSolutionButton":"Show solution","tryAgain":"Retry","wrongAnswerMessage":"Wrong answer","correctAnswerMessage":"Correct answer","scoreBarLabel":"You got :num out of :total points","a11yCheck":"Check the answers. The responses will be marked as correct, incorrect, or unanswered.","a11yShowSolution":"Show the solution. The task will be marked with its correct solution.","a11yRetry":"Retry the task. Reset all responses and start the task over again."},"confirmCheck":{"header":"Finish ?","body":"Are you sure you wish to finish ?","cancelLabel":"Cancel","confirmLabel":"Finish"},"confirmRetry":{"header":"Retry ?","body":"Are you sure you wish to retry ?","cancelLabel":"Cancel","confirmLabel":"Confirm"},"question":"
DNA polymerases take part in Transcription<\/p>\n"},"metadata":{"contentType":"True\/False Question","license":"CC BY-SA","title":"True\/False Question","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022},"subContentId":"7fa018b2-5e1e-4d23-81df-809528b84e14"},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""}],"slideBackgroundSelector":{}}],"keywordListEnabled":true,"keywordListAlwaysShow":false,"keywordListAutoHide":false,"keywordListOpacity":90,"globalBackgroundSelector":{"imageGlobalBackground":{"path":"images\/image-KE6cstMu.png","mime":"image\/png","copyright":{"license":"C","title":"Image background","author":"Ethiraj College for Women","year":"2022"},"width":1698,"height":820}}},"override":{"activeSurface":false,"hideSummarySlide":false,"summarySlideSolutionButton":true,"summarySlideRetryButton":true,"enablePrintButton":false,"social":{"showFacebookShare":false,"facebookShare":{"url":"@currentpageurl","quote":"I scored @score out of @maxScore on a task at @currentpageurl."},"showTwitterShare":false,"twitterShare":{"statement":"I scored @score out of @maxScore on a task at @currentpageurl.","url":"@currentpageurl","hashtags":"h5p, course"},"showGoogleShare":false,"googleShareUrl":"@currentpageurl"}},"l10n":{"slide":"Slide","score":"Score","yourScore":"Your Score","maxScore":"Max Score","total":"Total","totalScore":"Total Score","showSolutions":"Show solutions","retry":"Retry","exportAnswers":"Export text","hideKeywords":"Hide sidebar navigation menu","showKeywords":"Show sidebar navigation menu","fullscreen":"Fullscreen","exitFullscreen":"Exit fullscreen","prevSlide":"Previous slide","nextSlide":"Next slide","currentSlide":"Current slide","lastSlide":"Last slide","solutionModeTitle":"Exit solution mode","solutionModeText":"Solution Mode","summaryMultipleTaskText":"Multiple tasks","scoreMessage":"You achieved:","shareFacebook":"Share on Facebook","shareTwitter":"Share on Twitter","shareGoogle":"Share on Google+","summary":"Summary","solutionsButtonTitle":"Show comments","printTitle":"Print","printIngress":"How would you like to print this presentation?","printAllSlides":"Print all slides","printCurrentSlide":"Print current slide","noTitle":"No title","accessibilitySlideNavigationExplanation":"Use left and right arrow to change slide in that direction whenever canvas is selected.","accessibilityCanvasLabel":"Presentation canvas. Use left and right arrow to move between slides.","containsNotCompleted":"@slideName contains not completed interaction","containsCompleted":"@slideName contains completed interaction","slideCount":"Slide @index of @total","containsOnlyCorrect":"@slideName only has correct answers","containsIncorrectAnswers":"@slideName has incorrect answers","shareResult":"Share Result","accessibilityTotalScore":"You got @score of @maxScore points in total","accessibilityEnteredFullscreen":"Entered fullscreen","accessibilityExitedFullscreen":"Exited fullscreen","confirmDialogHeader":"Submit your answers","confirmDialogText":"This will submit your results, do you want to continue?","confirmDialogConfirmText":"Submit and see results"}},"library":"H5P.CoursePresentation 1.24","metadata":{"contentType":"Course Presentation","license":"CC BY-SA","title":"Gene Expression","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022},"subContentId":"f4e835bf-0ec1-4f10-b9bc-8d5f6a8d2607"},"useSeparator":"auto"}]},"library":"H5P.Column 1.15","subContentId":"75f055aa-6216-4f5a-bb5c-a64ef6dc653c","metadata":{"contentType":"Column","license":"CC BY-SA","title":"What is Gene Expression ?","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},{"params":{"content":[{"content":{"params":{"presentation":{"slides":[{"elements":[{"x":4.709576138147567,"y":12.40406233041321,"width":89.48194662480377,"height":18.606093495619813,"action":{"library":"H5P.AdvancedText 1.1","params":{"text":"
To understand why gene expression needs to regulated ?<\/strong><\/p>\n\n
Let us know about the two categories of genes namely House keeping genes<\/strong> and Tissue specific genes <\/strong><\/p>\n"},"subContentId":"b1dc88b3-abaf-42b7-b246-77ba32c26b15","metadata":{"contentType":"Text","license":"U","title":"Untitled Text"}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":3.139717425431711,"y":37.212186991239626,"width":41.569858712715856,"height":43.41421815644623,"action":{"library":"H5P.AdvancedText 1.1","params":{"text":"
House keeping genes <\/strong><\/p>\n\n
These are genes that are responsible for routine metabolic functions , common to all cells and required at all times .<\/p>\n\n
Example : GAPDH gene - Glyceraldehyde 3-Phosphate gene<\/strong><\/p>\n\n
<\/p>\n"},"metadata":{"contentType":"Text","license":"U","title":"Untitled Text"},"subContentId":"1d3b12c5-99fa-452e-9211-e5e60ba36ef0"},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":48.665620094191524,"y":37.212186991239626,"width":50.23547880690738,"height":49.61624932165284,"action":{"library":"H5P.AdvancedText 1.1","params":{"text":"
Tissue Specific genes <\/strong><\/p>\n\n
Some genes are expressed only as and when the cell needs and by specialised type of cells only.. These genes are called as Tissue specific genes <\/p>\n\n
Example : The antibody producing Plasma cell expresses the appropriate antibody gene only upon encountering an antigen.<\/strong><\/p>\n\n
<\/p>\n"},"metadata":{"contentType":"Text","license":"U","title":"Untitled Text"},"subContentId":"9f79ea15-3635-4b1e-a371-155c9a26f45c"},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""}],"slideBackgroundSelector":{}},{"elements":[{"x":3.139717425431711,"y":12.40406233041321,"width":42.3861852433281,"height":80.62640514768586,"action":{"library":"H5P.Image 1.1","params":{"contentName":"Image","file":{"path":"images\/image-sVixjdHn.png","mime":"image\/png","copyright":{"license":"U"},"width":2048,"height":1217}},"subContentId":"ca31ec9b-8c56-4442-b1d5-49c5508c127b","metadata":{"contentType":"Image","license":"CC BY-SA","title":"GAPDH","authors":[{"name":"Vossman","role":"Author"}],"licenseVersion":"3.0","yearFrom":2011}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":48.665620094191524,"y":12.40406233041321,"width":48.665620094191524,"height":64.8075044577099,"action":{"library":"H5P.Blanks 1.14","params":{"media":{"disableImageZooming":false},"text":"Fill in the missing words","overallFeedback":[{"from":0,"to":100}],"showSolutions":"Show solution","tryAgain":"Retry","checkAnswer":"Check","submitAnswer":"Submit","notFilledOut":"Please fill in all blanks to view solution","answerIsCorrect":"':ans' is correct","answerIsWrong":"':ans' is wrong","answeredCorrectly":"Answered correctly","answeredIncorrectly":"Answered incorrectly","solutionLabel":"Correct answer:","inputLabel":"Blank input @num of @total","inputHasTipLabel":"Tip available","tipLabel":"Tip","behaviour":{"enableRetry":true,"enableSolutionsButton":true,"enableCheckButton":true,"autoCheck":false,"caseSensitive":true,"showSolutionsRequiresInput":true,"separateLines":false,"confirmCheckDialog":false,"confirmRetryDialog":false,"acceptSpellingErrors":false},"scoreBarLabel":"You got :num out of :total points","a11yCheck":"Check the answers. The responses will be marked as correct, incorrect, or unanswered.","a11yShowSolution":"Show the solution. The task will be marked with its correct solution.","a11yRetry":"Retry the task. Reset all responses and start the task over again.","a11yCheckingModeHeader":"Checking mode","confirmCheck":{"header":"Finish ?","body":"Are you sure you wish to finish ?","cancelLabel":"Cancel","confirmLabel":"Finish"},"confirmRetry":{"header":"Retry ?","body":"Are you sure you wish to retry ?","cancelLabel":"Cancel","confirmLabel":"Confirm"},"questions":["
GAPDH is *Glyceraldehyde -3-Phosphate Dehydrogenase *<\/p>\n\n
GAPDH gene is a *House Keeping Gene*<\/p>\n\n
<\/p>\n"]},"subContentId":"4d183039-322e-4de6-aa72-b972a70703d0","metadata":{"contentType":"Fill in the Blanks","license":"CC BY-SA","title":"Fill in the Blanks","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""}],"slideBackgroundSelector":{}},{"elements":[{"x":4.709576138147567,"y":9.303046747809907,"width":43.956043956043956,"height":65.12132723466935,"action":{"library":"H5P.Image 1.1","params":{"contentName":"Image","file":{"path":"images\/image-iTHJh6P1.jpg","mime":"image\/jpeg","copyright":{"license":"U"},"width":639,"height":559,"originalImage":{"path":"images\/image-VhKJbe7U.jpg","mime":"image\/jpeg","height":705,"width":1214}},"alt":"Identify the type of the gene"},"subContentId":"a4214e74-aa27-4835-98df-2b72dac93856","metadata":{"contentType":"Image","license":"CC BY-SA","title":":Biochem-polyclonal production","authors":[{"name":"JackPotte","role":"Author"}],"licenseVersion":"3.0","yearFrom":2017,"source":"https:\/\/commons.wikimedia.org\/wiki\/File:Biochem-polyclonal_production.jpg"}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":53.37519623233909,"y":12.40406233041321,"width":43.13971742543171,"height":34.111171408636324,"action":{"library":"H5P.Blanks 1.14","params":{"media":{"disableImageZooming":false},"text":"Fill in the missing words","overallFeedback":[{"from":0,"to":100}],"showSolutions":"Show solution","tryAgain":"Retry","checkAnswer":"Check","submitAnswer":"Submit","notFilledOut":"Please fill in all blanks to view solution","answerIsCorrect":"':ans' is correct","answerIsWrong":"':ans' is wrong","answeredCorrectly":"Answered correctly","answeredIncorrectly":"Answered incorrectly","solutionLabel":"Correct answer:","inputLabel":"Blank input @num of @total","inputHasTipLabel":"Tip available","tipLabel":"Tip","behaviour":{"enableRetry":true,"enableSolutionsButton":true,"enableCheckButton":true,"autoCheck":false,"caseSensitive":true,"showSolutionsRequiresInput":true,"separateLines":false,"confirmCheckDialog":false,"confirmRetryDialog":false,"acceptSpellingErrors":false},"scoreBarLabel":"You got :num out of :total points","a11yCheck":"Check the answers. The responses will be marked as correct, incorrect, or unanswered.","a11yShowSolution":"Show the solution. The task will be marked with its correct solution.","a11yRetry":"Retry the task. Reset all responses and start the task over again.","a11yCheckingModeHeader":"Checking mode","confirmCheck":{"header":"Finish ?","body":"Are you sure you wish to finish ?","cancelLabel":"Cancel","confirmLabel":"Finish"},"confirmRetry":{"header":"Retry ?","body":"Are you sure you wish to retry ?","cancelLabel":"Cancel","confirmLabel":"Confirm"},"questions":["
* Plasma Cells * are antibodies producing B cells<\/p>\n"]},"subContentId":"6fbd9eaa-b028-41f4-bcee-e8b0de46041c","metadata":{"contentType":"Fill in the Blanks","license":"CC BY-SA","title":"Fill in the Blanks","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":51.80533751962323,"y":52.71726490425614,"width":43.956043956043956,"height":37.212186991239626,"action":{"library":"H5P.TrueFalse 1.8","params":{"media":{"disableImageZooming":false},"correct":"true","behaviour":{"enableRetry":true,"enableSolutionsButton":true,"enableCheckButton":true,"confirmCheckDialog":false,"confirmRetryDialog":false,"autoCheck":false},"l10n":{"trueText":"True","falseText":"False","score":"You got @score of @total points","checkAnswer":"Check","submitAnswer":"Submit","showSolutionButton":"Show solution","tryAgain":"Retry","wrongAnswerMessage":"Wrong answer","correctAnswerMessage":"Correct answer","scoreBarLabel":"You got :num out of :total points","a11yCheck":"Check the answers. The responses will be marked as correct, incorrect, or unanswered.","a11yShowSolution":"Show the solution. The task will be marked with its correct solution.","a11yRetry":"Retry the task. Reset all responses and start the task over again."},"confirmCheck":{"header":"Finish ?","body":"Are you sure you wish to finish ?","cancelLabel":"Cancel","confirmLabel":"Finish"},"confirmRetry":{"header":"Retry ?","body":"Are you sure you wish to retry ?","cancelLabel":"Cancel","confirmLabel":"Confirm"},"question":"
Antibody genes are Tissue specific genes<\/p>\n"},"subContentId":"582b84e0-7ac6-4b80-b713-0671d8d40822","metadata":{"contentType":"True\/False Question","license":"CC BY-SA","title":"True\/False Question","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""}],"slideBackgroundSelector":{}},{"elements":[{"x":3.139717425431711,"y":15.505077913016512,"width":45.52590266875981,"height":55.508178928599115,"action":{"library":"H5P.AdvancedText 1.1","params":{"text":"
<\/p>\n\n
\n\t
Gene regulation ensures that appropriate genes are expressed at appropriate time<\/span><\/li>\n\t
There by ensures that appropriate molecules needed by the cell are produced<\/span><\/li>\n\t
Gene regulation thus ensures appropriate functioning of cells <\/span><\/li>\n<\/ul>\n"},"metadata":{"contentType":"Text","license":"CC BY-SA","title":"Gene expression regulation","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022},"subContentId":"1e14f9aa-913e-43d1-88a8-41c35bee0963"},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":53.37519623233909,"y":9.303046747809907,"width":43.01020408163266,"height":61.2295526785022,"action":{"library":"H5P.Image 1.1","params":{"contentName":"Image","file":{"path":"images\/image-lhcEgJDW.png","mime":"image\/png","copyright":{"license":"U"},"width":600,"height":600},"alt":"Need for Gene regulation"},"metadata":{"contentType":"Image","license":"ODC PDDL","title":"Multitasking guy","authors":[{"name":"Gordon Dylan Johnson","role":"Author"}],"source":"https:\/\/openclipart.org\/detail\/261508\/multitasking-cartoon-man-with-original-background","yearFrom":2016},"subContentId":"755fc8b7-d8f4-4626-8983-3d30a47bd00d"},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":7.849293563579278,"y":77.52538956508256,"width":86.46781789638932,"height":20.15272501744321,"action":{"library":"H5P.AdvancedText 1.1","params":{"text":"
Thanks to the gene regulatory mechanisms of our cells so that we could appropriately perform our tasks<\/strong><\/span><\/p>\n"},"metadata":{"contentType":"Text","license":"CC BY-SA","title":"Gene expression regulation","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022},"subContentId":"3439907e-7b03-462d-b6da-05527333741f"},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""}],"slideBackgroundSelector":{}}],"keywordListEnabled":true,"keywordListAlwaysShow":false,"keywordListAutoHide":false,"keywordListOpacity":90,"globalBackgroundSelector":{"imageGlobalBackground":{"path":"images\/image-uoTmyKke.png","mime":"image\/png","copyright":{"license":"C","title":"Image Background","author":"Ethiraj College for Women","year":"2022"},"width":1698,"height":820}}},"override":{"activeSurface":false,"hideSummarySlide":false,"summarySlideSolutionButton":true,"summarySlideRetryButton":true,"enablePrintButton":false,"social":{"showFacebookShare":false,"facebookShare":{"url":"@currentpageurl","quote":"I scored @score out of @maxScore on a task at @currentpageurl."},"showTwitterShare":false,"twitterShare":{"statement":"I scored @score out of @maxScore on a task at @currentpageurl.","url":"@currentpageurl","hashtags":"h5p, course"},"showGoogleShare":false,"googleShareUrl":"@currentpageurl"}},"l10n":{"slide":"Slide","score":"Score","yourScore":"Your Score","maxScore":"Max Score","total":"Total","totalScore":"Total Score","showSolutions":"Show solutions","retry":"Retry","exportAnswers":"Export text","hideKeywords":"Hide sidebar navigation menu","showKeywords":"Show sidebar navigation menu","fullscreen":"Fullscreen","exitFullscreen":"Exit fullscreen","prevSlide":"Previous slide","nextSlide":"Next slide","currentSlide":"Current slide","lastSlide":"Last slide","solutionModeTitle":"Exit solution mode","solutionModeText":"Solution Mode","summaryMultipleTaskText":"Multiple tasks","scoreMessage":"You achieved:","shareFacebook":"Share on Facebook","shareTwitter":"Share on Twitter","shareGoogle":"Share on Google+","summary":"Summary","solutionsButtonTitle":"Show comments","printTitle":"Print","printIngress":"How would you like to print this presentation?","printAllSlides":"Print all slides","printCurrentSlide":"Print current slide","noTitle":"No title","accessibilitySlideNavigationExplanation":"Use left and right arrow to change slide in that direction whenever canvas is selected.","accessibilityCanvasLabel":"Presentation canvas. Use left and right arrow to move between slides.","containsNotCompleted":"@slideName contains not completed interaction","containsCompleted":"@slideName contains completed interaction","slideCount":"Slide @index of @total","containsOnlyCorrect":"@slideName only has correct answers","containsIncorrectAnswers":"@slideName has incorrect answers","shareResult":"Share Result","accessibilityTotalScore":"You got @score of @maxScore points in total","accessibilityEnteredFullscreen":"Entered fullscreen","accessibilityExitedFullscreen":"Exited fullscreen","confirmDialogHeader":"Submit your answers","confirmDialogText":"This will submit your results, do you want to continue?","confirmDialogConfirmText":"Submit and see results"}},"library":"H5P.CoursePresentation 1.24","metadata":{"contentType":"Course Presentation","license":"CC BY-SA","title":"Why Gene expression needs to be regulated ?","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022},"subContentId":"abdbcf55-2d86-4fe7-9bda-641030c81e51"},"useSeparator":"auto"}]},"library":"H5P.Column 1.15","subContentId":"ef559c08-b3d1-4ecc-9468-77b56d261a68","metadata":{"contentType":"Column","license":"CC BY-SA","title":"Why Gene Expression needs to be regulated ?","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},{"params":{"content":[{"content":{"params":{"presentation":{"slides":[{"elements":[{"x":6.279434850863422,"y":49.61624932165284,"width":28.92857142857143,"height":40.31320257384293,"action":{"library":"H5P.Image 1.1","params":{"contentName":"Image","file":{"path":"images\/image-s5CYxsrk.jpg","mime":"image\/jpeg","copyright":{"license":"U"},"width":400,"height":280},"alt":"Image to depict All same yet different"},"subContentId":"f5dfe8c2-79ac-4f64-9bf0-f8b6e0dc661f","metadata":{"contentType":"Image","license":"CC BY","title":"All same but different","authors":[{"name":"Indiana Ivy Nature Photographer","role":"Author"}],"licenseVersion":"2.0"}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":1.5698587127158556,"y":12.40406233041321,"width":40,"height":40.31320257384293,"action":{"library":"H5P.AdvancedText 1.1","params":{"text":"
\n\t
Surprisingly all cells contain the same DNA <\/span><\/strong><\/li>\n\t
Yet they produce different proteins and perform unique functions .<\/span><\/li>\n\t
How is this Possible ?<\/span><\/li>\n<\/ul>\n"},"subContentId":"f73c2de4-7b6b-4e49-9c69-41749d308279","metadata":{"contentType":"Text","license":"CC BY-SA","title":"Importance of Gene regulation","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":43.956043956043956,"y":6.202031165206605,"width":53.375196232339086,"height":55.81828048685944,"action":{"library":"H5P.AdvancedText 1.1","params":{"text":"
\n\t
This is made possible by varied gene regulation.<\/strong><\/li>\n\t
For example ,the gene that are transcribed from DNA, are modified by a process called Post Transcriptional modification <\/strong><\/li>\n\t
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Alternative Splicing or Differential Splicing <\/strong>is the mechanism by which a single gene can be made to code for different proteins <\/li>\n<\/ul>\n"},"subContentId":"4e392ec5-c7b2-46e4-9dcf-8aa660d9e2db","metadata":{"contentType":"Text","license":"CC BY-SA","title":"Gene expression regulation","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":50.23547880690738,"y":59.84960074424374,"width":48.665620094191524,"height":39.999379796883474,"action":{"library":"H5P.Image 1.1","params":{"contentName":"Image","file":{"path":"images\/image-ADCu4Atb.jpg","mime":"image\/jpeg","copyright":{"license":"U"},"width":960,"height":641},"alt":"Example of Alphabets joining- for Gene Splicing"},"subContentId":"3cdff9d7-6202-49ce-b6a7-7c17c511bfdf","metadata":{"contentType":"Image","license":"ODC PDDL","title":"Word letters free stock image","authors":[{"name":"Firstname Surname","role":"Author"}]}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":7.849293563579278,"y":77.52538956508256,"width":37.67660910518053,"height":15.505077913016512,"action":{"library":"H5P.AdvancedText 1.1","params":{"text":"
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Ribonucleoprotein particles<\/div>\n"},{"correct":false,"tipsAndFeedback":{"tip":"","chosenFeedback":"","notChosenFeedback":""},"text":"
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\n\t
Humans and Chimpanzees have a DNA that is nearly 98 % identical<\/strong><\/span><\/li>\n\t
But their protein coding sequences of the genes are different<\/span><\/li>\n\t
This is a response of varied gene expression regulation<\/span><\/li>\n\t
This contributes to the difference between the two species <\/span><\/li>\n<\/ul>\n"},"subContentId":"c4187e26-0b23-4c26-a29e-4573b78c545a","metadata":{"contentType":"Text","license":"CC BY-SA","title":"Example to show the importance of varied gene regulation","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":3.139717425431711,"y":18.606093495619813,"width":37.67660910518053,"height":62.02031165206605,"action":{"library":"H5P.Image 1.1","params":{"contentName":"Image","file":{"path":"images\/image-73VvLORZ.jpg","mime":"image\/jpeg","copyright":{"license":"U"},"width":960,"height":662}},"subContentId":"91ffebee-80c9-4d8b-9505-824f57049fdb","metadata":{"contentType":"Image","license":"PD","title":"Evolution development Future","authors":[{"name":"Firstname Surname","role":"Author"}]}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""}],"slideBackgroundSelector":{}},{"elements":[{"x":3.1397174254317113,"y":18.606093495619813,"width":40,"height":40,"action":{"library":"H5P.TrueFalse 1.8","params":{"media":{"disableImageZooming":false},"correct":"true","behaviour":{"enableRetry":true,"enableSolutionsButton":true,"enableCheckButton":true,"confirmCheckDialog":false,"confirmRetryDialog":false,"autoCheck":false},"l10n":{"trueText":"True","falseText":"False","score":"You got @score of @total points","checkAnswer":"Check","submitAnswer":"Submit","showSolutionButton":"Show solution","tryAgain":"Retry","wrongAnswerMessage":"Wrong answer","correctAnswerMessage":"Correct answer","scoreBarLabel":"You got :num out of :total points","a11yCheck":"Check the answers. The responses will be marked as correct, incorrect, or unanswered.","a11yShowSolution":"Show the solution. The task will be marked with its correct solution.","a11yRetry":"Retry the task. Reset all responses and start the task over again."},"confirmCheck":{"header":"Finish ?","body":"Are you sure you wish to finish ?","cancelLabel":"Cancel","confirmLabel":"Finish"},"confirmRetry":{"header":"Retry ?","body":"Are you sure you wish to retry ?","cancelLabel":"Cancel","confirmLabel":"Confirm"},"question":"
All cells contain the same DNA<\/p>\n"},"subContentId":"a38e2192-0ab7-4803-a089-2dd4805e6245","metadata":{"contentType":"True\/False Question","license":"CC BY-SA","title":"True\/False Question","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":53.375196232339086,"y":9.303046747809907,"width":40,"height":40,"action":{"library":"H5P.TrueFalse 1.8","params":{"media":{"disableImageZooming":false},"correct":"false","behaviour":{"enableRetry":true,"enableSolutionsButton":true,"enableCheckButton":true,"confirmCheckDialog":false,"confirmRetryDialog":false,"autoCheck":false},"l10n":{"trueText":"True","falseText":"False","score":"You got @score of @total points","checkAnswer":"Check","submitAnswer":"Submit","showSolutionButton":"Show solution","tryAgain":"Retry","wrongAnswerMessage":"Wrong answer","correctAnswerMessage":"Correct answer","scoreBarLabel":"You got :num out of :total points","a11yCheck":"Check the answers. The responses will be marked as correct, incorrect, or unanswered.","a11yShowSolution":"Show the solution. The task will be marked with its correct solution.","a11yRetry":"Retry the task. Reset all responses and start the task over again."},"confirmCheck":{"header":"Finish ?","body":"Are you sure you wish to finish ?","cancelLabel":"Cancel","confirmLabel":"Finish"},"confirmRetry":{"header":"Retry ?","body":"Are you sure you wish to retry ?","cancelLabel":"Cancel","confirmLabel":"Confirm"},"question":"
A single gene cannot be made to code for different proteins<\/p>\n"},"subContentId":"dbcd98d5-5a6a-436f-83bd-1c1bff0acf9b","metadata":{"contentType":"True\/False Question","license":"CC BY-SA","title":"True\/False Question","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":21.978021978021978,"y":59.5394991859834,"width":56.5149136577708,"height":40.31320257384293,"action":{"library":"H5P.TrueFalse 1.8","params":{"media":{"disableImageZooming":false},"correct":"false","behaviour":{"enableRetry":true,"enableSolutionsButton":true,"enableCheckButton":true,"confirmCheckDialog":false,"confirmRetryDialog":false,"autoCheck":false},"l10n":{"trueText":"True","falseText":"False","score":"You got @score of @total points","checkAnswer":"Check","submitAnswer":"Submit","showSolutionButton":"Show solution","tryAgain":"Retry","wrongAnswerMessage":"Wrong answer","correctAnswerMessage":"Correct answer","scoreBarLabel":"You got :num out of :total points","a11yCheck":"Check the answers. The responses will be marked as correct, incorrect, or unanswered.","a11yShowSolution":"Show the solution. The task will be marked with its correct solution.","a11yRetry":"Retry the task. Reset all responses and start the task over again."},"confirmCheck":{"header":"Finish ?","body":"Are you sure you wish to finish ?","cancelLabel":"Cancel","confirmLabel":"Finish"},"confirmRetry":{"header":"Retry ?","body":"Are you sure you wish to retry ?","cancelLabel":"Cancel","confirmLabel":"Confirm"},"question":"
The DNA of humans and chimpanzees are 98% identical and produce the same proteins<\/p>\n"},"subContentId":"68066f45-899c-49fb-b8a3-24db759f2ca6","metadata":{"contentType":"True\/False Question","license":"CC BY-SA","title":"True\/False Question","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""}],"slideBackgroundSelector":{}}],"keywordListEnabled":true,"keywordListAlwaysShow":false,"keywordListAutoHide":false,"keywordListOpacity":90,"globalBackgroundSelector":{"imageGlobalBackground":{"path":"images\/image-oI75rXux.png","mime":"image\/png","copyright":{"license":"C","title":"Image background","author":"Ethiraj College for Women","year":"2022"},"width":1698,"height":820}}},"override":{"activeSurface":false,"hideSummarySlide":false,"summarySlideSolutionButton":true,"summarySlideRetryButton":true,"enablePrintButton":false,"social":{"showFacebookShare":false,"facebookShare":{"url":"@currentpageurl","quote":"I scored @score out of @maxScore on a task at @currentpageurl."},"showTwitterShare":false,"twitterShare":{"statement":"I scored @score out of @maxScore on a task at @currentpageurl.","url":"@currentpageurl","hashtags":"h5p, course"},"showGoogleShare":false,"googleShareUrl":"@currentpageurl"}},"l10n":{"slide":"Slide","score":"Score","yourScore":"Your Score","maxScore":"Max Score","total":"Total","totalScore":"Total Score","showSolutions":"Show solutions","retry":"Retry","exportAnswers":"Export text","hideKeywords":"Hide sidebar navigation menu","showKeywords":"Show sidebar navigation menu","fullscreen":"Fullscreen","exitFullscreen":"Exit fullscreen","prevSlide":"Previous slide","nextSlide":"Next slide","currentSlide":"Current slide","lastSlide":"Last slide","solutionModeTitle":"Exit solution mode","solutionModeText":"Solution Mode","summaryMultipleTaskText":"Multiple tasks","scoreMessage":"You achieved:","shareFacebook":"Share on Facebook","shareTwitter":"Share on Twitter","shareGoogle":"Share on Google+","summary":"Summary","solutionsButtonTitle":"Show comments","printTitle":"Print","printIngress":"How would you like to print this presentation?","printAllSlides":"Print all slides","printCurrentSlide":"Print current slide","noTitle":"No title","accessibilitySlideNavigationExplanation":"Use left and right arrow to change slide in that direction whenever canvas is selected.","accessibilityCanvasLabel":"Presentation canvas. Use left and right arrow to move between slides.","containsNotCompleted":"@slideName contains not completed interaction","containsCompleted":"@slideName contains completed interaction","slideCount":"Slide @index of @total","containsOnlyCorrect":"@slideName only has correct answers","containsIncorrectAnswers":"@slideName has incorrect answers","shareResult":"Share Result","accessibilityTotalScore":"You got @score of @maxScore points in total","accessibilityEnteredFullscreen":"Entered fullscreen","accessibilityExitedFullscreen":"Exited fullscreen","confirmDialogHeader":"Submit your answers","confirmDialogText":"This will submit your results, do you want to continue?","confirmDialogConfirmText":"Submit and see results"}},"library":"H5P.CoursePresentation 1.24","metadata":{"contentType":"Course Presentation","license":"CC BY-SA","title":"Importance of Gene expression regulation","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022},"subContentId":"edbeb1b2-f003-4b41-b740-100691332805"},"useSeparator":"auto"}]},"library":"H5P.Column 1.15","subContentId":"75c376bd-87f2-488e-8351-92b7ffc65d18","metadata":{"contentType":"Column","license":"CC BY-SA","title":"Importance of Gene regulation","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},{"params":{"content":[{"content":{"params":{"presentation":{"slides":[{"elements":[{"x":3.1397174254317113,"y":9.303046747809907,"width":91.05180533751962,"height":18.606093495619813,"action":{"library":"H5P.AdvancedText 1.1","params":{"text":"
\n\t
Default state of gene expression in eukaryotes is rather \"off \" than \" on\"<\/strong><\/span><\/li>\n<\/ul>\n"},"subContentId":"a8969af9-1800-47d1-8097-ebf548c44508","metadata":{"contentType":"Text","license":"CC BY-SA","title":"How are genes regulated ?","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":9.419152276295135,"y":34.111171408636324,"width":83.20251177394034,"height":52.403442127296685,"action":{"library":"H5P.AdvancedText 1.1","params":{"text":"
Gene expression can be regulated at the level of Transcription, Translation and by modifying the DNA & Chromatin architecture <\/span><\/p>\n\n
Lets us learn more about Gene expression regulation by<\/span><\/p>\n\n
\n\t
DNA Methylation<\/span><\/li>\n\t
Histone Modification<\/span><\/li>\n\t
Chromatin Remodeling<\/span><\/li>\n<\/ul>\n"},"subContentId":"8e070d6e-1cb6-4fdd-827b-3ff28ad94343","metadata":{"contentType":"Text","license":"CC BY-SA","title":"Gene expression regulation","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""}],"slideBackgroundSelector":{}},{"elements":[{"x":31.39717425431711,"y":9.303046747809907,"width":40.2668759811617,"height":15.505077913016512,"action":{"library":"H5P.AdvancedText 1.1","params":{"text":"
<\/p>\n\n
DNA Methylation<\/strong><\/span><\/p>\n"},"subContentId":"9a10e514-a5a6-4e7a-82ef-00bb4885616a","metadata":{"contentType":"Text","license":"U","title":"Untitled Text"}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":7.849293563579278,"y":27.90914024342972,"width":89.48194662480377,"height":58.919296069462746,"action":{"library":"H5P.AdvancedText 1.1","params":{"text":"
\n\t
DNA methylation is the process of adding methyl tags to the bases of the DNA<\/span><\/li>\n\t
This reaction is carried out by enzymes called DNA Methyl Transferases (DMTs)<\/strong><\/span><\/li>\n\t
The cytosine and Guanine bases of the DNA are more frequently methylated <\/span><\/li>\n\t
The cytosine \/ guanine rich regions of the genes are called CpG Islands <\/strong><\/span><\/li>\n\t
DNA methylation in the promoter regions can repress Gene transcription as it interferes with the binding of transcription factors<\/strong><\/span><\/li>\n<\/ul>\n"},"subContentId":"e17dbcdd-44b5-4d7b-900c-7c263a294e83","metadata":{"contentType":"Text","license":"CC BY-SA","title":"DNA methylation-Gene expression regulation","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""}],"slideBackgroundSelector":{}},{"elements":[{"x":4.7095761381475665,"y":31.010155826033024,"width":44.11874972056095,"height":40,"action":{"library":"H5P.Image 1.1","params":{"contentName":"Image","file":{"path":"images\/image-NbDOAHJa.png","mime":"image\/png","copyright":{"license":"U"},"width":634,"height":291}},"subContentId":"7c7fb90b-317e-4474-8651-37d92bb20f84","metadata":{"contentType":"Image","license":"CC BY-SA","title":"DNA methylation","authors":[{"name":"Mariuswalter","role":"Author"}],"licenseVersion":"4.0","source":"https:\/\/commons.wikimedia.org\/wiki\/File:DNA_methylation.png","yearFrom":2016}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":54.94505494505495,"y":21.707109078223116,"width":40,"height":52.403442127296685,"action":{"library":"H5P.Blanks 1.14","params":{"media":{"disableImageZooming":false},"text":"Fill in the missing words","overallFeedback":[{"from":0,"to":100}],"showSolutions":"Show solution","tryAgain":"Retry","checkAnswer":"Check","submitAnswer":"Submit","notFilledOut":"Please fill in all blanks to view solution","answerIsCorrect":"':ans' is correct","answerIsWrong":"':ans' is wrong","answeredCorrectly":"Answered correctly","answeredIncorrectly":"Answered incorrectly","solutionLabel":"Correct answer:","inputLabel":"Blank input @num of @total","inputHasTipLabel":"Tip available","tipLabel":"Tip","behaviour":{"enableRetry":true,"enableSolutionsButton":true,"enableCheckButton":true,"autoCheck":false,"caseSensitive":true,"showSolutionsRequiresInput":true,"separateLines":false,"confirmCheckDialog":false,"confirmRetryDialog":false,"acceptSpellingErrors":false},"scoreBarLabel":"You got :num out of :total points","a11yCheck":"Check the answers. The responses will be marked as correct, incorrect, or unanswered.","a11yShowSolution":"Show the solution. The task will be marked with its correct solution.","a11yRetry":"Retry the task. Reset all responses and start the task over again.","a11yCheckingModeHeader":"Checking mode","confirmCheck":{"header":"Finish ?","body":"Are you sure you wish to finish ?","cancelLabel":"Cancel","confirmLabel":"Finish"},"confirmRetry":{"header":"Retry ?","body":"Are you sure you wish to retry ?","cancelLabel":"Cancel","confirmLabel":"Confirm"},"questions":["
Cytosine is methylated at *C5* position<\/p>\n"]},"subContentId":"98d264cd-43f1-416e-9d5c-e3f2e8bf381b","metadata":{"contentType":"Fill in the Blanks","license":"CC BY-SA","title":"Fill in the Blanks","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""}],"slideBackgroundSelector":{}},{"elements":[{"x":6.279434850863422,"y":18.606093495619813,"width":93.72056514913658,"height":71.0095356229165,"action":{"library":"H5P.DragText 1.10","params":{"taskDescription":"Drag the words into the correct boxes","overallFeedback":[{"from":0,"to":100}],"checkAnswer":"Check","submitAnswer":"Submit","tryAgain":"Retry","showSolution":"Show solution","dropZoneIndex":"Drop Zone @index.","empty":"Drop Zone @index is empty.","contains":"Drop Zone @index contains draggable @draggable.","ariaDraggableIndex":"@index of @count draggables.","tipLabel":"Show tip","correctText":"Correct!","incorrectText":"Incorrect!","resetDropTitle":"Reset drop","resetDropDescription":"Are you sure you want to reset this drop zone?","grabbed":"Draggable is grabbed.","cancelledDragging":"Cancelled dragging.","correctAnswer":"Correct answer:","feedbackHeader":"Feedback","behaviour":{"enableRetry":true,"enableSolutionsButton":true,"enableCheckButton":true,"instantFeedback":false},"scoreBarLabel":"You got :num out of :total points","a11yCheck":"Check the answers. The responses will be marked as correct, incorrect, or unanswered.","a11yShowSolution":"Show the solution. The task will be marked with its correct solution.","a11yRetry":"Retry the task. Reset all responses and start the task over again.","textField":"*DNA methyl transferase* methylates DNA\n*C and G* bases of DNA are frequently methylated \nThe dinucleotide ,C and G rich repetitive regions of DNA are called *CpG Islands*\nDNA methylation in promoter region *repress* gene transcription."},"metadata":{"contentType":"Drag the Words","license":"CC BY-SA","title":"Drag the Words","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022},"subContentId":"f4903b23-a383-4074-9399-0cec3887e77c"},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""}],"slideBackgroundSelector":{}},{"elements":[{"x":4.709576138147567,"y":15.505077913016512,"width":58.084772370486654,"height":77.52538956508256,"action":{"library":"H5P.Video 1.6","params":{"visuals":{"fit":true,"controls":true},"playback":{"autoplay":false,"loop":false},"l10n":{"name":"Video","loading":"Video player loading...","noPlayers":"Found no video players that supports the given video format.","noSources":"Video is missing sources.","aborted":"Media playback has been aborted.","networkFailure":"Network failure.","cannotDecode":"Unable to decode media.","formatNotSupported":"Video format not supported.","mediaEncrypted":"Media encrypted.","unknownError":"Unknown error.","invalidYtId":"Invalid YouTube ID.","unknownYtId":"Unable to find video with the given YouTube ID.","restrictedYt":"The owner of this video does not allow it to be embedded."},"sources":[{"path":"https:\/\/www.youtube.com\/watch?v=8M-pgs_ugpk","mime":"video\/YouTube","copyright":{"license":"U"}}]},"subContentId":"5d7b869f-7a93-4be3-9f84-467c56d9a540","metadata":{"contentType":"Video","license":"C","title":"Video on DNA methylation and varied Gene expression","authors":[{"name":"DNA Learning Center","role":"Author"}],"source":"http:\/\/ https:\/\/dnalc.cshl.edu\/resources\/dnal."}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":67.50188383045527,"y":18.606093495619813,"width":32.464678178963894,"height":61.706488875106594,"action":{"library":"H5P.Blanks 1.14","params":{"media":{"disableImageZooming":false},"text":"Fill in the missing words","overallFeedback":[{"from":0,"to":100}],"showSolutions":"Show solution","tryAgain":"Retry","checkAnswer":"Check","submitAnswer":"Submit","notFilledOut":"Please fill in all blanks to view solution","answerIsCorrect":"':ans' is correct","answerIsWrong":"':ans' is wrong","answeredCorrectly":"Answered correctly","answeredIncorrectly":"Answered incorrectly","solutionLabel":"Correct answer:","inputLabel":"Blank input @num of @total","inputHasTipLabel":"Tip available","tipLabel":"Tip","behaviour":{"enableRetry":true,"enableSolutionsButton":true,"enableCheckButton":true,"autoCheck":false,"caseSensitive":true,"showSolutionsRequiresInput":true,"separateLines":false,"confirmCheckDialog":false,"confirmRetryDialog":false,"acceptSpellingErrors":false},"scoreBarLabel":"You got :num out of :total points","a11yCheck":"Check the answers. 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* Epigenetics* is the study of how cell modifies gene expression without changing the DNA sequence<\/p>\n\n
DNA Methyltion is an * Epigenetic* Phenomenon <\/p>\n"]},"subContentId":"1c804bb7-a3bf-4fdd-b6de-809584632bef","metadata":{"contentType":"Fill in the Blanks","license":"CC BY-SA","title":"Fill in the Blanks","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""}],"slideBackgroundSelector":{}}],"keywordListEnabled":true,"keywordListAlwaysShow":false,"keywordListAutoHide":false,"keywordListOpacity":90,"globalBackgroundSelector":{"imageGlobalBackground":{"path":"images\/image-Z4SK1BRj.png","mime":"image\/png","copyright":{"license":"C","title":"Image background","author":"Ethiraj College for Women","year":"2022"},"width":1698,"height":820}}},"override":{"activeSurface":false,"hideSummarySlide":false,"summarySlideSolutionButton":true,"summarySlideRetryButton":true,"enablePrintButton":false,"social":{"showFacebookShare":false,"facebookShare":{"url":"@currentpageurl","quote":"I scored @score out of @maxScore on a task at @currentpageurl."},"showTwitterShare":false,"twitterShare":{"statement":"I scored @score out of @maxScore on a task at @currentpageurl.","url":"@currentpageurl","hashtags":"h5p, course"},"showGoogleShare":false,"googleShareUrl":"@currentpageurl"}},"l10n":{"slide":"Slide","score":"Score","yourScore":"Your Score","maxScore":"Max Score","total":"Total","totalScore":"Total Score","showSolutions":"Show solutions","retry":"Retry","exportAnswers":"Export text","hideKeywords":"Hide sidebar navigation menu","showKeywords":"Show sidebar navigation menu","fullscreen":"Fullscreen","exitFullscreen":"Exit fullscreen","prevSlide":"Previous slide","nextSlide":"Next slide","currentSlide":"Current slide","lastSlide":"Last slide","solutionModeTitle":"Exit solution mode","solutionModeText":"Solution Mode","summaryMultipleTaskText":"Multiple tasks","scoreMessage":"You achieved:","shareFacebook":"Share on Facebook","shareTwitter":"Share on Twitter","shareGoogle":"Share on Google+","summary":"Summary","solutionsButtonTitle":"Show comments","printTitle":"Print","printIngress":"How would you like to print this presentation?","printAllSlides":"Print all slides","printCurrentSlide":"Print current slide","noTitle":"No title","accessibilitySlideNavigationExplanation":"Use left and right arrow to change slide in that direction whenever canvas is selected.","accessibilityCanvasLabel":"Presentation canvas. Use left and right arrow to move between slides.","containsNotCompleted":"@slideName contains not completed interaction","containsCompleted":"@slideName contains completed interaction","slideCount":"Slide @index of @total","containsOnlyCorrect":"@slideName only has correct answers","containsIncorrectAnswers":"@slideName has incorrect answers","shareResult":"Share Result","accessibilityTotalScore":"You got @score of @maxScore points in total","accessibilityEnteredFullscreen":"Entered fullscreen","accessibilityExitedFullscreen":"Exited fullscreen","confirmDialogHeader":"Submit your answers","confirmDialogText":"This will submit your results, do you want to continue?","confirmDialogConfirmText":"Submit and see results"}},"library":"H5P.CoursePresentation 1.24","metadata":{"contentType":"Course Presentation","license":"CC BY-SA","title":"How are genes regulated ?","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022},"subContentId":"19c3915c-6775-46fb-a565-2fb276fce24e"},"useSeparator":"auto"}]},"library":"H5P.Column 1.15","subContentId":"d22b1528-a64a-4266-8c9d-8525a639de03","metadata":{"contentType":"Column","license":"U","title":"How are genes regulated ?"}},{"params":{"content":[{"content":{"params":{"presentation":{"slides":[{"elements":[{"x":45.52590266875981,"y":3.1010155826033023,"width":53.375196232339086,"height":88.9138692921932,"action":{"library":"H5P.AdvancedText 1.1","params":{"text":"
What are Histones ?<\/strong><\/p>\n\n
\n\t
Histones are the basic proteins <\/strong>that bind the DNA. as they are rich in Arginine and lysine residues <\/li>\n\t
Hence they more tightly bind the DNA<\/li>\n\t
Histones helps in the compaction of DNA so that the 6 feet DNA can be packaged inside a very small nucleus of the cell.<\/li>\n\t
There are 5 sub types of histone proteins namely H1, H2A,H2B,H3, and H4 <\/strong><\/li>\n\t
H2A,H2B,H3, and H4 constitute the histone octamers that form the Nucleosomes <\/strong><\/li>\n<\/ul>\n"},"subContentId":"b33898cd-689c-4273-9c8e-2d667c316a6d","metadata":{"contentType":"Text","license":"CC BY-SA","title":"What are Histones","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":6.279434850863422,"y":15.505077913016512,"width":34.53689167974882,"height":71.32335839987596,"action":{"library":"H5P.Image 1.1","params":{"contentName":"Image","file":{"path":"images\/image-5PXrjAGo.jpg","mime":"image\/jpeg","copyright":{"license":"U"},"width":743,"height":584},"alt":"Role of Histones"},"subContentId":"b601014c-c1d5-46c8-a0e1-8ce49d7f2e62","metadata":{"contentType":"Image","license":"CC BY-SA","title":"DNA macrostructure","authors":[{"name":"OpenStax, CC BY 4.0 <https:\/\/creativecommons.org\/licenses\/by\/4.0>, via Wikimedia Commons","role":"Author"}],"licenseVersion":"4.0","yearFrom":2016}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":4.7095761381475665,"y":88.92170793528922,"width":38.69701726844584,"height":11.078378168850298,"action":{"library":"H5P.AdvancedText 1.1","params":{"text":"
Histones binding and compacting the DNA <\/strong><\/p>\n"},"subContentId":"ad8aeff1-e1f7-476c-ab23-5d5c232f6661","metadata":{"contentType":"Text","license":"U","title":"Untitled Text"}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""}],"slideBackgroundSelector":{}},{"elements":[{"x":4.709576138147567,"y":15.505077913016512,"width":89.48194662480377,"height":74.42437398247925,"action":{"library":"H5P.AdvancedText 1.1","params":{"text":"
How are Histones modified ?<\/strong><\/p>\n\n
Histones can be modified by <\/span><\/p>\n\n
\n\t
Acetylation<\/span><\/li>\n\t
Methylation<\/span><\/li>\n\t
Phosphorylation <\/span><\/li>\n\t
Sumoylation etc.,<\/span><\/li>\n<\/ul>\n\n
Let us explore more about Histone Acetylation and its impact on gene expression.<\/span><\/p>\n"},"subContentId":"cc02818d-ced9-4b90-8e02-c837e0584a07","metadata":{"contentType":"Text","license":"CC BY-SA","title":"Gene expression regulation-Histone modification","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""}],"slideBackgroundSelector":{}},{"elements":[{"x":3.139717425431711,"y":12.40406233041321,"width":95.76138147566719,"height":86.82843631289246,"action":{"library":"H5P.AdvancedText 1.1","params":{"text":"
Histone modification -Acetylation & Deactylation <\/strong><\/p>\n\n
\n\t
Histone are Acetylated <\/strong>by enzymes called Histone Acetylases or HATs<\/strong><\/span><\/li>\n\t
While histones are deacetylated <\/strong>by enzymes called Histone Deacetylases or HDACs<\/strong><\/span><\/li>\n\t
When histones are acetylated<\/strong> there is a decrease in their positive charge<\/span><\/li>\n\t
As the result cannot bind the negatively charged DNA <\/span><\/li>\n\t
Hence leaves the DNA or Chromtin decondses <\/span><\/li>\n\t
Genes are exposed to transcription machinery- gene expression is\" turned on\"<\/span><\/li>\n\t
On the otherhand when Histones are deacteylated <\/strong><\/span><\/li>\n\t
The negative charges of acettate group is removed <\/span><\/li>\n\t
Positive charge of histone predominate<\/span><\/li>\n\t
,Hence binds DNA more tightly, Chromatin is more condensed - Gene expression is \"turned off\"<\/strong><\/span><\/li>\n<\/ul>\n\n
<\/p>\n"},"subContentId":"908900dc-9ce0-40b1-b4d6-847c1c01f804","metadata":{"contentType":"Text","license":"CC BY-SA","title":"Histone modification - Acetylation and deacetylation","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""}],"slideBackgroundSelector":{}},{"elements":[{"x":59.65463108320251,"y":3.1010155826033023,"width":40,"height":40,"action":{"library":"H5P.TrueFalse 1.8","params":{"media":{"disableImageZooming":false},"correct":"true","behaviour":{"enableRetry":true,"enableSolutionsButton":true,"enableCheckButton":true,"confirmCheckDialog":false,"confirmRetryDialog":false,"autoCheck":false},"l10n":{"trueText":"True","falseText":"False","score":"You got @score of @total points","checkAnswer":"Check","submitAnswer":"Submit","showSolutionButton":"Show solution","tryAgain":"Retry","wrongAnswerMessage":"Wrong answer","correctAnswerMessage":"Correct answer","scoreBarLabel":"You got :num out of :total points","a11yCheck":"Check the answers. The responses will be marked as correct, incorrect, or unanswered.","a11yShowSolution":"Show the solution. The task will be marked with its correct solution.","a11yRetry":"Retry the task. Reset all responses and start the task over again."},"confirmCheck":{"header":"Finish ?","body":"Are you sure you wish to finish ?","cancelLabel":"Cancel","confirmLabel":"Finish"},"confirmRetry":{"header":"Retry ?","body":"Are you sure you wish to retry ?","cancelLabel":"Cancel","confirmLabel":"Confirm"},"question":"
Histone modification is an epigenetic phenomenon<\/p>\n"},"subContentId":"558abc23-82a5-42cd-9b2e-86dab76d2172","metadata":{"contentType":"True\/False Question","license":"CC BY-SA","title":"True\/False Question","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":59.65463108320251,"y":52.71726490425614,"width":40,"height":40,"action":{"library":"H5P.TrueFalse 1.8","params":{"media":{"disableImageZooming":false},"correct":"false","behaviour":{"enableRetry":true,"enableSolutionsButton":true,"enableCheckButton":true,"confirmCheckDialog":false,"confirmRetryDialog":false,"autoCheck":false},"l10n":{"trueText":"True","falseText":"False","score":"You got @score of @total points","checkAnswer":"Check","submitAnswer":"Submit","showSolutionButton":"Show solution","tryAgain":"Retry","wrongAnswerMessage":"Wrong answer","correctAnswerMessage":"Correct answer","scoreBarLabel":"You got :num out of :total points","a11yCheck":"Check the answers. The responses will be marked as correct, incorrect, or unanswered.","a11yShowSolution":"Show the solution. The task will be marked with its correct solution.","a11yRetry":"Retry the task. Reset all responses and start the task over again."},"confirmCheck":{"header":"Finish ?","body":"Are you sure you wish to finish ?","cancelLabel":"Cancel","confirmLabel":"Finish"},"confirmRetry":{"header":"Retry ?","body":"Are you sure you wish to retry ?","cancelLabel":"Cancel","confirmLabel":"Confirm"},"question":"
When histone is deacetylated Gene expression is turned on <\/p>\n"},"subContentId":"53f50f23-65f3-4cde-a68e-c3d05f3e7fca","metadata":{"contentType":"True\/False Question","license":"CC BY-SA","title":"True \/False","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":3.139717425431711,"y":21.707109078223116,"width":54.94505494505494,"height":49.30242654469338,"action":{"library":"H5P.AdvancedText 1.1","params":{"text":"
<\/p>\n\n
Watch the video on Epigenetics , Histone modifications and gene regulation by clicking the link given below <\/span><\/p>\n\n
https:\/\/youtu.be\/eYrQ0EhVCYA<\/a><\/p>\n"},"subContentId":"150ff5f5-b247-49b6-bc9e-17780dc78542","metadata":{"contentType":"Text","license":"U","title":"Watch the video"}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""}],"slideBackgroundSelector":{}},{"elements":[{"x":6.279434850863422,"y":15.505077913016512,"width":91.05180533751962,"height":80.62640514768586,"action":{"library":"H5P.DragText 1.10","params":{"taskDescription":"Drag the words into the correct boxes","overallFeedback":[{"from":0,"to":100}],"checkAnswer":"Check","submitAnswer":"Submit","tryAgain":"Retry","showSolution":"Show solution","dropZoneIndex":"Drop Zone @index.","empty":"Drop Zone @index is empty.","contains":"Drop Zone @index contains draggable @draggable.","ariaDraggableIndex":"@index of @count draggables.","tipLabel":"Show tip","correctText":"Correct!","incorrectText":"Incorrect!","resetDropTitle":"Reset drop","resetDropDescription":"Are you sure you want to reset this drop zone?","grabbed":"Draggable is grabbed.","cancelledDragging":"Cancelled dragging.","correctAnswer":"Correct answer:","feedbackHeader":"Feedback","behaviour":{"enableRetry":true,"enableSolutionsButton":true,"enableCheckButton":true,"instantFeedback":false},"scoreBarLabel":"You got :num out of :total points","a11yCheck":"Check the answers. The responses will be marked as correct, incorrect, or unanswered.","a11yShowSolution":"Show the solution. The task will be marked with its correct solution.","a11yRetry":"Retry the task. Reset all responses and start the task over again.","textField":"DNA is *negatively* Charged \nHistone are *positively* charged\nHistones are basic proteins rich in *Arginine & Lysine*\nStudy of heritable phenotypic modification brought about without modifying DNA seguence is *Epigentics*\n* Histone modification & DNA methylation* are epigenetic phenomenon"},"subContentId":"2896da6a-5da6-460e-a2e3-3bed0f240fb7","metadata":{"contentType":"Drag the Words","license":"CC BY-SA","title":"Drag the Words","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""}],"slideBackgroundSelector":{}}],"keywordListEnabled":true,"keywordListAlwaysShow":false,"keywordListAutoHide":false,"keywordListOpacity":90,"globalBackgroundSelector":{"imageGlobalBackground":{"path":"images\/image-x7yPnuA6.png","mime":"image\/png","copyright":{"license":"C","title":"Image background","author":"Ethiraj College for Women","year":"2022"},"width":1698,"height":820}}},"override":{"activeSurface":false,"hideSummarySlide":false,"summarySlideSolutionButton":true,"summarySlideRetryButton":true,"enablePrintButton":false,"social":{"showFacebookShare":false,"facebookShare":{"url":"@currentpageurl","quote":"I scored @score out of @maxScore on a task at @currentpageurl."},"showTwitterShare":false,"twitterShare":{"statement":"I scored @score out of @maxScore on a task at @currentpageurl.","url":"@currentpageurl","hashtags":"h5p, course"},"showGoogleShare":false,"googleShareUrl":"@currentpageurl"}},"l10n":{"slide":"Slide","score":"Score","yourScore":"Your Score","maxScore":"Max Score","total":"Total","totalScore":"Total Score","showSolutions":"Show solutions","retry":"Retry","exportAnswers":"Export text","hideKeywords":"Hide sidebar navigation menu","showKeywords":"Show sidebar navigation menu","fullscreen":"Fullscreen","exitFullscreen":"Exit fullscreen","prevSlide":"Previous slide","nextSlide":"Next slide","currentSlide":"Current slide","lastSlide":"Last slide","solutionModeTitle":"Exit solution mode","solutionModeText":"Solution Mode","summaryMultipleTaskText":"Multiple tasks","scoreMessage":"You achieved:","shareFacebook":"Share on Facebook","shareTwitter":"Share on Twitter","shareGoogle":"Share on Google+","summary":"Summary","solutionsButtonTitle":"Show comments","printTitle":"Print","printIngress":"How would you like to print this presentation?","printAllSlides":"Print all slides","printCurrentSlide":"Print current slide","noTitle":"No title","accessibilitySlideNavigationExplanation":"Use left and right arrow to change slide in that direction whenever canvas is selected.","accessibilityCanvasLabel":"Presentation canvas. Use left and right arrow to move between slides.","containsNotCompleted":"@slideName contains not completed interaction","containsCompleted":"@slideName contains completed interaction","slideCount":"Slide @index of @total","containsOnlyCorrect":"@slideName only has correct answers","containsIncorrectAnswers":"@slideName has incorrect answers","shareResult":"Share Result","accessibilityTotalScore":"You got @score of @maxScore points in total","accessibilityEnteredFullscreen":"Entered fullscreen","accessibilityExitedFullscreen":"Exited fullscreen","confirmDialogHeader":"Submit your answers","confirmDialogText":"This will submit your results, do you want to continue?","confirmDialogConfirmText":"Submit and see results"}},"library":"H5P.CoursePresentation 1.24","metadata":{"contentType":"Course Presentation","license":"CC BY-SA","title":"Gene regulation by histone modifications","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022},"subContentId":"0fd05f25-1900-46ac-ac3f-d7e88d7ac86c"},"useSeparator":"auto"}]},"library":"H5P.Column 1.15","subContentId":"cb6b54ae-0f25-42ae-8845-c8c7dd2f11c8","metadata":{"contentType":"Column","license":"CC BY-SA","title":"Gene regulation by Histone modification","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},{"params":{"content":[{"content":{"params":{"presentation":{"slides":[{"elements":[{"x":7.849293563579278,"y":18.606093495619813,"width":80.06279434850863,"height":68.22234281727265,"action":{"library":"H5P.AdvancedText 1.1","params":{"text":"
Chromatin remodeling is the dynamic modification of chromatin architecture .<\/strong><\/span><\/p>\n\n
Heterochromatin<\/strong><\/span><\/p>\n\n
\n\t
When chromatin is condensed ,DNA is tightly packed<\/span><\/li>\n\t
it becomes inaccessible to the transcrition machinery <\/span><\/li>\n\t
Thereby gene expression is \"turned off\"<\/span><\/li>\n\t
In this state chromatin is called Heterochromatin and is transcriptionally inactive <\/span><\/li>\n<\/ul>\n"},"subContentId":"f35b8f35-6642-436d-a4c4-26dec0724b66","metadata":{"contentType":"Text","license":"CC BY-SA","title":"Active, Inactive genes","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""}],"slideBackgroundSelector":{}},{"elements":[{"x":10.989010989010989,"y":18.606093495619813,"width":83.20251177394034,"height":62.02031165206605,"action":{"library":"H5P.AdvancedText 1.1","params":{"text":"
Euchromatin<\/strong><\/span><\/p>\n\n
\n\t
When chromatin is deconsed it is called as relaxed \/ open chromatin<\/span><\/li>\n\t
Now it becomes accessible to the transcription machinery <\/span><\/li>\n\t
Gene expression is \"turned on \" <\/strong><\/span><\/li>\n\t
Such a actively transcribing chromatin is called \"Euchromatin\"<\/span><\/li>\n<\/ul>\n"},"subContentId":"9f7787bc-7074-4888-83db-44e3ea39b3dc","metadata":{"contentType":"Text","license":"CC BY-SA","title":"Euchromatin","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""}],"slideBackgroundSelector":{}},{"elements":[{"x":9.419152276295135,"y":15.505077913016512,"width":80.06279434850863,"height":80.29304597255602,"action":{"library":"H5P.Image 1.1","params":{"contentName":"Image","file":{"path":"images\/image-5M8wmLVe.png","mime":"image\/png","copyright":{"license":"U"},"width":725,"height":561},"alt":"Active ,Inactive genes"},"subContentId":"a146e07f-3afa-43d8-919d-a5f26592218e","metadata":{"contentType":"Image","license":"CC BY-SA","title":"Inactive, active genes","authors":[{"name":"https:\/\/openstax.org\/books\/biology-2e\/pages\/1-introduction","role":"Author"}],"licenseVersion":"4.0","source":"http:\/\/cnx.org\/contents\/185cbf87-c72e-48f5-b51e-f14f21b5eabd@10.8"}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""}],"slideBackgroundSelector":{}},{"elements":[{"x":6.279434850863423,"y":15.505077913016512,"width":83.20251177394034,"height":80.62640514768586,"action":{"library":"H5P.Blanks 1.14","params":{"media":{"disableImageZooming":false},"text":"Fill in the missing words","overallFeedback":[{"from":0,"to":100}],"showSolutions":"Show solution","tryAgain":"Retry","checkAnswer":"Check","submitAnswer":"Submit","notFilledOut":"Please fill in all blanks to view solution","answerIsCorrect":"':ans' is correct","answerIsWrong":"':ans' is wrong","answeredCorrectly":"Answered correctly","answeredIncorrectly":"Answered incorrectly","solutionLabel":"Correct answer:","inputLabel":"Blank input @num of @total","inputHasTipLabel":"Tip available","tipLabel":"Tip","behaviour":{"enableRetry":true,"enableSolutionsButton":true,"enableCheckButton":true,"autoCheck":false,"caseSensitive":true,"showSolutionsRequiresInput":true,"separateLines":false,"confirmCheckDialog":false,"confirmRetryDialog":false,"acceptSpellingErrors":false},"scoreBarLabel":"You got :num out of :total points","a11yCheck":"Check the answers. The responses will be marked as correct, incorrect, or unanswered.","a11yShowSolution":"Show the solution. The task will be marked with its correct solution.","a11yRetry":"Retry the task. Reset all responses and start the task over again.","a11yCheckingModeHeader":"Checking mode","confirmCheck":{"header":"Finish ?","body":"Are you sure you wish to finish ?","cancelLabel":"Cancel","confirmLabel":"Finish"},"confirmRetry":{"header":"Retry ?","body":"Are you sure you wish to retry ?","cancelLabel":"Cancel","confirmLabel":"Confirm"},"questions":["
Dynamic Change in the architecture of chromatin is *Chromatin remodeling*<\/p>\n\n
Dencondensed state of chromatin is *Euchromatin*<\/p>\n\n
Condensed chromtin is *heterochromatin*<\/p>\n\n
*Euchromatin* is Transcritionally active<\/p>\n\n
*Heterochromatin* Transcriptionally inactive<\/p>\n"]},"subContentId":"b184d937-7377-43f9-86be-571cf620826c","metadata":{"contentType":"Fill in the Blanks","license":"CC BY-SA","title":"Fill in the Blanks","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""}],"slideBackgroundSelector":{}},{"elements":[{"x":7.849293563579278,"y":9.303046747809907,"width":86.34222919937206,"height":90.6969532521901,"action":{"library":"H5P.AdvancedText 1.1","params":{"text":"
How is Chromatin Remodeling done?<\/strong><\/p>\n\n
\n\tChromatin is remodelled with the help of\n\t
\n\t\t
Histone modifying ezymes (Refer page 6) and<\/li>\n\t<\/ul>\n\t<\/li>\n\t
With the help of chromatin remodeling factors <\/strong><\/li>\n<\/ul>\n\n
<\/p>\n\n
What are Chromatin remodeling factors ?<\/strong><\/p>\n\n
\n\t
These are proteins that remodel chromatin<\/li>\n\t
They are called Chromatin remodelers<\/li>\n\t
Example of eukaryotic chromatin remodelers is SWI\/SNF, <\/li>\n\t
These shift the nucleosome position with respect to DNA and expose the regulatory sequence <\/li>\n\t
Thereby modify gene expression<\/li>\n<\/ul>\n"},"subContentId":"db4491b5-245e-4451-a569-c36f472b6f7b","metadata":{"contentType":"Text","license":"CC BY-SA","title":"How is chromatin remodeled ?","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""}],"slideBackgroundSelector":{}},{"elements":[{"x":9.419152276295135,"y":13.865415923715016,"width":81.63265306122449,"height":76.0601597023025,"action":{"library":"H5P.Image 1.1","params":{"contentName":"Image","file":{"path":"images\/image-IUycU2ND.jpg","mime":"image\/jpeg","copyright":{"license":"U"},"width":1200,"height":537},"alt":"Chromatin Remodeling"},"subContentId":"01e0cca6-1f8d-497b-80d5-7b47488bc99b","metadata":{"contentType":"Image","license":"CC BY-SA","title":"Chromatin remodeling","authors":[{"name":"Luong, P","role":"Author"}],"licenseVersion":"3.0","source":"http:\/\/cnx.org\/content\/m26565\/1.1\/] (2009)","yearFrom":2009}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""}],"slideBackgroundSelector":{}},{"elements":[{"x":1.5698587127158556,"y":15.505077913016512,"width":45.52590266875981,"height":46.515233739049535,"action":{"library":"H5P.TrueFalse 1.8","params":{"media":{"disableImageZooming":false},"correct":"true","behaviour":{"enableRetry":true,"enableSolutionsButton":true,"enableCheckButton":true,"confirmCheckDialog":false,"confirmRetryDialog":false,"autoCheck":false},"l10n":{"trueText":"True","falseText":"False","score":"You got @score of @total points","checkAnswer":"Check","submitAnswer":"Submit","showSolutionButton":"Show solution","tryAgain":"Retry","wrongAnswerMessage":"Wrong answer","correctAnswerMessage":"Correct answer","scoreBarLabel":"You got :num out of :total points","a11yCheck":"Check the answers. The responses will be marked as correct, incorrect, or unanswered.","a11yShowSolution":"Show the solution. The task will be marked with its correct solution.","a11yRetry":"Retry the task. Reset all responses and start the task over again."},"confirmCheck":{"header":"Finish ?","body":"Are you sure you wish to finish ?","cancelLabel":"Cancel","confirmLabel":"Finish"},"confirmRetry":{"header":"Retry ?","body":"Are you sure you wish to retry ?","cancelLabel":"Cancel","confirmLabel":"Confirm"},"question":"
Histone modifying enzymes modify chromatin struture<\/p>\n"},"subContentId":"064138d0-48a9-4f98-ad4e-990b84a6449e","metadata":{"contentType":"True\/False Question","license":"CC BY-SA","title":"True\/False Question","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""},{"x":50.23547880690738,"y":46.515233739049535,"width":45.52590266875981,"height":46.515233739049535,"action":{"library":"H5P.TrueFalse 1.8","params":{"media":{"disableImageZooming":false},"correct":"true","behaviour":{"enableRetry":true,"enableSolutionsButton":true,"enableCheckButton":true,"confirmCheckDialog":false,"confirmRetryDialog":false,"autoCheck":false},"l10n":{"trueText":"True","falseText":"False","score":"You got @score of @total points","checkAnswer":"Check","submitAnswer":"Submit","showSolutionButton":"Show solution","tryAgain":"Retry","wrongAnswerMessage":"Wrong answer","correctAnswerMessage":"Correct answer","scoreBarLabel":"You got :num out of :total points","a11yCheck":"Check the answers. The responses will be marked as correct, incorrect, or unanswered.","a11yShowSolution":"Show the solution. The task will be marked with its correct solution.","a11yRetry":"Retry the task. Reset all responses and start the task over again."},"confirmCheck":{"header":"Finish ?","body":"Are you sure you wish to finish ?","cancelLabel":"Cancel","confirmLabel":"Finish"},"confirmRetry":{"header":"Retry ?","body":"Are you sure you wish to retry ?","cancelLabel":"Cancel","confirmLabel":"Confirm"},"question":"
SWI\/SNF proteins shifts nucleosome position<\/p>\n"},"metadata":{"contentType":"True\/False Question","license":"CC BY-SA","title":"True\/False Question","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022},"subContentId":"bb45e855-a94d-4c4a-ad91-f42518b96058"},"alwaysDisplayComments":false,"backgroundOpacity":0,"displayAsButton":false,"buttonSize":"big","goToSlideType":"specified","invisible":false,"solution":""}],"slideBackgroundSelector":{}}],"keywordListEnabled":true,"keywordListAlwaysShow":false,"keywordListAutoHide":false,"keywordListOpacity":90,"globalBackgroundSelector":{"imageGlobalBackground":{"path":"images\/image-58rtF9DC.png","mime":"image\/png","copyright":{"license":"C","title":"Image Background","author":"Ethiraj College for Women","year":"2022"},"width":1698,"height":820}}},"override":{"activeSurface":false,"hideSummarySlide":false,"summarySlideSolutionButton":true,"summarySlideRetryButton":true,"enablePrintButton":false,"social":{"showFacebookShare":false,"facebookShare":{"url":"@currentpageurl","quote":"I scored @score out of @maxScore on a task at @currentpageurl."},"showTwitterShare":false,"twitterShare":{"statement":"I scored @score out of @maxScore on a task at @currentpageurl.","url":"@currentpageurl","hashtags":"h5p, course"},"showGoogleShare":false,"googleShareUrl":"@currentpageurl"}},"l10n":{"slide":"Slide","score":"Score","yourScore":"Your Score","maxScore":"Max Score","total":"Total","totalScore":"Total Score","showSolutions":"Show solutions","retry":"Retry","exportAnswers":"Export text","hideKeywords":"Hide sidebar navigation menu","showKeywords":"Show sidebar navigation menu","fullscreen":"Fullscreen","exitFullscreen":"Exit fullscreen","prevSlide":"Previous slide","nextSlide":"Next slide","currentSlide":"Current slide","lastSlide":"Last slide","solutionModeTitle":"Exit solution mode","solutionModeText":"Solution Mode","summaryMultipleTaskText":"Multiple tasks","scoreMessage":"You achieved:","shareFacebook":"Share on Facebook","shareTwitter":"Share on Twitter","shareGoogle":"Share on Google+","summary":"Summary","solutionsButtonTitle":"Show comments","printTitle":"Print","printIngress":"How would you like to print this presentation?","printAllSlides":"Print all slides","printCurrentSlide":"Print current slide","noTitle":"No title","accessibilitySlideNavigationExplanation":"Use left and right arrow to change slide in that direction whenever canvas is selected.","accessibilityCanvasLabel":"Presentation canvas. Use left and right arrow to move between slides.","containsNotCompleted":"@slideName contains not completed interaction","containsCompleted":"@slideName contains completed interaction","slideCount":"Slide @index of @total","containsOnlyCorrect":"@slideName only has correct answers","containsIncorrectAnswers":"@slideName has incorrect answers","shareResult":"Share Result","accessibilityTotalScore":"You got @score of @maxScore points in total","accessibilityEnteredFullscreen":"Entered fullscreen","accessibilityExitedFullscreen":"Exited fullscreen","confirmDialogHeader":"Submit your answers","confirmDialogText":"This will submit your results, do you want to continue?","confirmDialogConfirmText":"Submit and see results"}},"library":"H5P.CoursePresentation 1.24","metadata":{"contentType":"Course Presentation","license":"CC BY-SA","title":"Active, Inactive genes","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022},"subContentId":"8aeb74b5-acd1-4c68-98f0-fe64f257d3f2"},"useSeparator":"auto"}]},"library":"H5P.Column 1.15","subContentId":"836d6d99-f825-4ffd-97f3-25548ab01af6","metadata":{"contentType":"Column","license":"CC BY-SA","title":"Chromatin Remodeling","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022}},{"params":{"content":[{"content":{"params":{"text":"
For Further reading readers can explore the following OERs<\/p>\n\n
\n\t
https:\/\/openstax.org\/details\/books\/biology-ap-courses<\/a><\/li>\n\t
https:\/\/courses.lumenlearning.com\/wm-biology1\/chapter\/outcome-regulation-of-gene-expression\/<\/a><\/li>\n\t
https:\/\/bio.libretexts.org\/Bookshelves\/Genetics\/Book%3A_Online_Open_Genetics_(Nickle_and_Barrette-g)\/12%3A_Regulation_of_Gene_Expression\/12.03%3A_Eukaryotic_Gene_Regulation<\/a><\/li>\n\t
https:\/\/www.oercommons.org\/courseware\/lesson\/15016\/overview<\/a><\/li>\n<\/ul>\n"},"library":"H5P.AdvancedText 1.1","metadata":{"contentType":"Text","license":"CC BY-SA","title":"Further Reading","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0","yearFrom":2022},"subContentId":"691800c6-4738-4abe-9444-0adfc3bd83c5"},"useSeparator":"auto"}]},"library":"H5P.Column 1.15","subContentId":"b62d9a7b-8295-4da7-98ea-0283963c9735","metadata":{"contentType":"Column","license":"CC BY-SA","title":"For Further reading","authors":[{"name":"Malathi.V","role":"Author"}],"licenseVersion":"4.0"}}],"behaviour":{"defaultTableOfContents":true,"progressIndicators":true,"progressAuto":true,"displaySummary":true},"read":"Read","displayTOC":"Display 'Table of contents'","hideTOC":"Hide 'Table of contents'","nextPage":"Next page","previousPage":"Previous page","chapterCompleted":"Page completed!","partCompleted":"@pages of @total completed","incompleteChapter":"Incomplete page","navigateToTop":"Navigate to the top","markAsFinished":"I have finished this page","fullscreen":"Fullscreen","exitFullscreen":"Exit fullscreen","bookProgressSubtext":"@count of @total pages","interactionsProgressSubtext":"@count of @total interactions","submitReport":"Submit Report","restartLabel":"Restart","summaryHeader":"Summary","allInteractions":"All interactions","unansweredInteractions":"Unanswered interactions","scoreText":"@score \/ @maxscore","leftOutOfTotalCompleted":"@left of @max interactions completed","noInteractions":"No interactions","score":"Score","summaryAndSubmit":"Summary & submit","noChapterInteractionBoldText":"You have not interacted with any pages.","noChapterInteractionText":"You have to interact with at least one page before you can see the summary.","yourAnswersAreSubmittedForReview":"Your answers are submitted for review!","bookProgress":"Book progress","interactionsProgress":"Interactions progress","totalScoreLabel":"Total score","a11y":{"progress":"Page @page of @total.","menu":"Toggle navigation menu"}}